CROSS-BRIDGE PROPERTIES DERIVED FROM MUSCLE ISOTONIC VELOCITY TRANSIENTS
نویسندگان
چکیده
منابع مشابه
Cross-bridge properties derived from muscle isotonic velocity transients.
The rate constants for the turnover of cross-bridges during frog muscle contraction were determined from an analysis of the motion that follows step decreases in load. For a given projection from the myosin filament, there appears to be a range of about 100 A along the length of the filament over which the projection can attach to the actin filament and form a cross-bridge. The site of attachme...
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Force and motion generated by skeletal muscle ultimately depends on the cyclical interaction of actin with myosin. This mechanical process is regulated by intracellular Ca(2+) through the thin filament-associated regulatory proteins i.e.; troponins and tropomyosin. Muscular dystrophies are a group of heterogeneous genetic affections characterized by progressive degeneration and weakness of the ...
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A mathematical formula was derived from an active cross-bridge model to express the changes in the active myocardial force which occurred during systole. Using the formula and the assumption that the energy expenditure for cross-bridge cycling (Um) was a linear function of the force-time integral (FTI), we developed formulae describing the left ventricular Um versus FTI relation, the Um versus ...
متن کاملSmooth muscle myosin cross-bridge interactions modulate actin filament sliding velocity in vitro
Although it is generally believed that phosphorylation of the regulatory light chain of myosin is required before smooth muscle can develop force, it is not known if the overall degree of phosphorylation can also modulate the rate at which cross-bridges cycle. To address this question, an in vitro motility assay was used to observe the motion of single actin filaments interacting with smooth mu...
متن کاملMathematical simulation of muscle cross-bridge cycle and force-velocity relationship.
Muscle contraction underlies many essential functions such as breathing, heart beating, locomotion, regulation of blood pressure, and airway resistance. Active shortening of muscle is the result of cycling of myosin cross-bridges that leads to sliding of myosin filaments relative to actin filaments. In this study, we have developed a computer program that allows us to alter the rates of transit...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1969
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.64.2.504